This is a proprietary Hovione technology for addressing complex particle reduction challenges.

Hovione developed wet polishing as a solution for generating 100% stable crystalline material which is recovered utilizing a spray drying process.

Wet polishing is a process that combines two integrated technologies: one to attain a small particle size (either a bottom-up technique such as controlled crystallization or nanocrystallization or top down technique such as high shear mixing or high pressure homogenization); and two to isolate the particles (for example spray drying or filtration followed by a drying process). This combination can be used to fine tune particle size and morphology in order to meet specific drug delivery requirements.


Powders for inhalation

Powders with very tight particle size distributions

Micronized powders for oral delivery

Micro- and nanoparticles used to overcome solubility limitations of BCS class 2 and 4 drugs


  • Optimal control over Particle Size Distribution (PSD), which is reproducible
  • Extremely narrow PSD spans
  • Particle customization; including surface area and surface charge
  • Easily scalable
  • Reduced amorphization


  • Requires an appropriate anti-solvent
  • Requires an isolation step
  • Challenging for thermally unstable compounds

Contact Us

Please contact us if you have inquiries about our offering

Also in Technologies

Hot melt extrusion

Hot melt extrusion is a fast growing technology platform thas is utilized to solve difficult formulation challenges, primarily in the area of solubilization.


Jet milling

Jet milling is widely used in the pharmaceutical industry and remains the leading technology for particle size reduction and is most commonly used for having consistent and uniform particles during formulation.



At Hovione we have both top-down and bottom-up technologies to produce pharmaceutical nanoparticles for oral delivery.


Spray congealing

Spray congealing, also known as spray cooling, is a solvent free process that transforms a melt into well defined spherical particles.


Spray drying

Spray drying has become one of the most successful particle engineering technologies for improving drug bioavailability through the amorphous solid dispersion platform.