Spray drying

Spray drying is a continuous process that can be used for multiple applications. Over the last 19 years, the technology has been used for the production of solid dispersions and is the fastest growing platform to overcome the solubility issues related to oral drugs, it is also relevant to inhalable particles, specialty excipients and for the isolation of thermally labile products. How it works The feed (a solution, emulsion or suspension) is atomized into hot nitrogen leading to flash (rapid) drying and particle formation. The particles are then separated in a cyclone and/or filter bag.   Applications   Solid dispersions Amorphous materials (drug + polymer) used to overcome solubility limitations of BCS class 2 and 4 drugs. Both drug and polymer need to dissolve in the solvent system. Microencapsulated particles Crystalline drug encapsulated with a coating polymer. For example, enteric polymers can be used to protect the drug from the gastric conditions or for enhanced delivery to the site of maximum absorption. Similar approaches can be used for taste masking and for protecting the drug from physical environments (e.g. light, moisture). Inhaled powders Ability to control particle size, morphology and other properties with direct effect in Fine Particle Fraction (FPF) and lung deposition. Spray drying is also the method of choice for materials that cannot withstand abrasion or shearing, like biologics. Hence, it is the preferred option for new the generation of inhaled formulations for biologics. Isolation of thermally labile materials Due to the gentle nature of the process it can be used to isolate materials that degrade during conventional isolation processes.   Learn more about Spray Drying and how to improve your drug solubility with the comprehensive three-part webinar series: "Amorphous Solid Dispersions by Spray Drying: From Early Formulation to Commercial Lifecycle Management"  Session 1: Evaluating the Best Formulations for Amorphous Solid Dispersions by Spray Drying  Session 2: ASDs by Spray Drying: Process Development & Scale-Up Session 3: Commercial Reality and Lifecycle Management of ASDs   As an experienced manufacturer of ASDs by spray drying for the pharmaceutical industry, Hovione will be able to share its extensive knowledge and experience.   Learn more about Spray Drying, with the following article by Hovione's experts: Spray Drying as an Enabling Technology for Inhalation Drug Delivery (PharmTech) Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery (Pharmaceutical Research)   Contact us