The most efficient synthetic routes of many products often require the use of low temperature reactions. The necessity for low temperature may be to generate and stabilize transient reactive intermediates (e.g. organometallics) or to slow down reactions to avoid undesired side reactions and/or to improve stereoselectivity.
Hovione has an abundance of experience in carrying out reactions at low temperatures in a GMP environment and has the requisite cryogenic capacity to support the scale-up and subsequent commercialization of related processes at large scale. This capability is available at various sites and our full capabilities are summarized below.
Please talk to us if your project involves cryogenic chemistry and you wish to partner with an organization that excels in scale up of low temperature transformations at scale.
|Site||Reactor capacity||Temp. Range ºC||Material of Construction|
|Loures||2000 L||-100 to 100||Stainless steel|
|4000 L||-50 to 200||Hastelloy|
|5000 L||-120 to 150||Hastelloy|
|Macau||6000 L||-65 to 140||Hastelloy|
|Cork||8000 L||-100 to 120||Hastelloy|
|10000 L||-150 to 120||Stainless steel|
|New Jersey||100 L||-78 to 120||Hastelloy|
|400 L||-78 to 120||Hastelloy|