Knowledge Center
Impact of Spray Drying on Superoxide Dismutase Activity in Composite Systems with Optimal Aerodynamic Performance for Dry Powder Inhalers
Inhaled biopharmaceutical formulations are increasingly attractive to treat not only a wide range of respiratory but also systemic diseases given:
- The lungs large surface area available for drug absorption and the avoidance of first-pass metabolism;
- Biopharmaceuticals (BP) higher specificity, lower toxicity and more predictable in vivo action over small molecules
However,
Efficient delivery of biopharmaceuticals to the lungs still presents a challenge:
- The generation of a stable aerosol with adequate aerodynamic properties while preserving the biopharmaceutical (BP) integrity.
Thus,
Particle engineering technology employed to meet this balance plays a pivotal role – Spray Drying (SD) emerges as a viable candidate:
- From an inhalation standpoint: Relative simplicity, cost effectiveness and scalability with increased control over key aerosol features;
- From a biopharmaceutical standpoint: Mild temperature exposure, commercial availability of miniaturized SD set-ups
Goal: Spray Drying assessment as a suitable particle engineering technology for the production of composite inhalable powders featuring a model biopharmaceutical