Pharmaceutical services to grow for another year
C&EN, 17 January 2022
in-PharmaTechnologist, September 3, 2019
Portugal-based Hovione Technology, a company developing inhalation devices, announced it has entered a collaboration agreement with the Kiel University’s Institute of Pharmacy in Germany.
The agreement will see scientists from the institution utilize Hovione’s portfolio of large dose dry-powder inhalers (DPIs) to conduct research on advanced formulation approaches for high-dose inhalation applications.
João Ventura Fernandes, Hovione’s director of technology, development and licensing, told us that the collaboration started in July 2019 and will continue during the course of the next three years.
Specifically, researchers will use Hovione’s TwinMax and 8Shot inhalation devices, which enable administration of powder doses of up to 400mg to patients lungs through multiple inhalations manoeuvres. The devices are suitable for inhaled delivery of antibiotics, peptides, anti-virals, vaccines, pain or rescue treatments.
Using Hovione’s devices, the researchers will work on formulations containing softpellets and nanocrystals for high-dose administration via dry powder inhalation, and with antibiotics including clarithromycin and rifampicin as model drugs.
"In high dose drug delivery, the key in inhaled formulation development is to create an active pharmaceutical ingredient (API)-rich formulation, i.e. with as little as possible excipients, to deliver the required therapeutic dose with the smallest amount of material as possible," Regina Scherließ, director of the Institute of Pharmacy, told us.
Scherließ added that, in order to achieve this goal, while concurrently maintaining handling and dispersion properties, the Institute develops two advanced formulation approaches:
Fernandes said that Hovione aims to answer market needs, after the introduction of new drugs requiring delivery of large lung doses, often within the range of 50 to 150mg. Indications of such drugs include cystic fibrosis, pulmonary arterial hypertension, idiopathic pulmonary fibrosis or lung infections.
Earlier this year, Hovione acquired from Med & Tec the rights to the design of Papillon, a reusable, cost-effective, dry powder inhaler suitable for administration of treatments for chronic or acute pulmonary conditions.
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C&EN, 17 January 2022