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Article / Apr 28, 2023

Capsule filling for DPIs - Linking Process scales through advanced characterisation and Quality by Design

ONDrugDelivery, 28 April 2023

Capsule filling for DPIs | Hovione

In this article, Rui Churro, PhD, Senior Scientist, Carolina Lopes, Associate Scientist, and João Pires, PhD, R&D Manager, all of Hovione’s Inhalation and Advanced Drug Delivery group, discuss the value of rheological characterisation of powders to expedite and de-risk the scale-up of DPI capsule-filling processes.

Composite particles are gaining traction as an alternative formulation strategy for dry powder inhalers. Typically, these engineered particles present low densities and small aerodynamic particle size, promoting an effective delivery to the lung. However, these unique properties can also raise operational challenges, such as poor flowability and powder agglomeration, during downstream filling processes. Since dry powder inhalers may contain doses as low as few milligrams, it is essential to understand the rheologic properties of the filled powders and select the best filling technology/conditions towards reaching the required filling accuracy.

Hovione has been deeply investing in developing formulation/process development strategies together with... Read more

 

 

 

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CDMO Hovione and biotechnology company Firstgene Life Sciences (of Xlife Sciences) have collaborated to advance Hovione’s drug delivery platform for the targeted treatment of Hepatocellular Carcinoma (HCC). “We are proud to advance the development of innovative oncology treatments that address a critical unmet need for precision gene expression at the tissue level,” said Hovione CEO Dr Jean-Luc Herbeaux. The virus-like particle technology will be engineered and functionalised for the specific carcinoma cell type using therapeutically validated AAVs, including a novel primer compound. Hovione will be responsible for molecular engineering, the supply of tailor-made virus-like particles and the execution of proof-of-concept studies. “HCC, the most common liver cancer and a leading cause of cancer-related death, continues to represent a major unmet medical need,” said Firstgene managing director Dr Alexander Zink. “The combination of Hovione’s expertise in complex chemistry and particle engineering and the commercialisation expertise of Xlife Sciences positions Firstgene well to offer patients potential new safe and effective therapy options.”   Read the full article at scientistlive.com    

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Dear Customer, As you may be aware, Portugal and Spain experienced yesterday, April 28 (at approximately 11:30) a widespread power outage. This unexpected event, beyond our control, affected the normal activities at our sites in Portugal. In response, we promptly activated our contingency protocols for this type of situation, prioritizing the safety of facilities and personnel. All ongoing processes were taken to safe hold points, and no new processes were initiated. Our backup power generators ensured continuity of critical functions throughout the duration of the outage, which lasted approximately 11 hours, until the power from the grid was restored at the site. The site began resuming operations gradually through the night making sure all systems being restarted safely and verified to be in good working conditions. We anticipate that most activities will be fully resumed during today. Should you have any specific questions regarding your product or project, we kindly encourage you to contact your Account Manager or Project Manager, who will be glad to assist you. We sincerely appreciate your understanding and continued partnership.      

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Widespread power outage in Portugal - Message to our clients

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In a recent appearance on CNN Portugal’s Pitch – Brand & Content program, Ilda Ventura, Senior Vice President of Human Resources at Hovione, highlighted a powerful reality: 55% of our employees in Science, Technology, Engineering, and Mathematics (STEM) roles are women. At Hovione, we’re proud to foster an environment where women in science thrive - leading innovation, driving progress, and shaping the future of healthcare. But our commitment goes beyond numbers - it’s about creating the right conditions for scientific talent to grow, equally and globally. “I am proud to say that, in our company, there is no gender pay gap between men and women. We empower everyone. Our female and male scientists are all working to find more sustainable, faster, and more productive ways to achieve victories over diseases.” - Ilda Ventura Watch the full edition to learn more about our commitment to women in science at CNNPortugal.pt  (Language: Portuguese)  

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