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Patent / Jan 01, 1973

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs

Authors:

Ivan Villax

Source:

GB 1397267

Pregnatrienedione I was prepd. from epoxypregnanetrione II in 7 steps. Thus, II underwent ketalization with HOCH2CH2OH, KBH4 redn., dehydration, Grignard reaction with MeMgBr, and deketalization to give pregnenedione III. III was treated with Br2-HOAc and then debrominated to I.

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Knowledge Center

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs

Also in the Knowledge Center

Methodology for rapid development of a continuous loss-in-weight feeding process

A review of the state-of-the-art: progress in ultrasonic and acoustic techniques for quality assessment in the development and manufacturing of oral solid dosage forms - Part I: theoretical foundations and principles

An integrated analytical approach to evaluate powder aggregation and predict the aerodynamic performance of homogeneous powders

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