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Article / Sep 25, 2021

Dry powder inhaler formulation comparison: Study of the role of particle deposition pattern and dissolution

Authors:
  • Beatriz Noriega Fernandes
  • Maria Malmlof
  • Mattias Nowenwik
  • Per Gerde
  • Luisa Corvo
  • Eunice Costa
Source:
International Journal of Pharmaceutics (Amsterdam, Netherlands) (2021), 607, 121025

The composition, morphol. and dissolution profile of particles and micro-sized agglomerates delivered upon inhalation may have a significant impact on the product clin. effect. However, although several efforts are ongoing, a methodol. that considers deposition structures and dissolution performance evaluation in a biorelevant set-up is not yet standardized. The goal of this work is to apply a collection and dissolution methodol. able to discriminate dry powder inhaler (DPI) formulations in terms of deposition structures and dissolution profile in vitro. Hence, Fluticasone Propionate (FP) engineered particles and formulated products (used as a case study) were collected employing a breath simulator and characterized regarding (i) aerodynamic particle size distribution; (ii) deposited microstructures; and (iii) dissolution/absorption profiles using the DissolvIt bio-relevant dissolution equipment. The results indicated that the particle engineering technol. had an impact on the generated and deposited microstructures, here associated to the differences on surface properties of jet milled and wet polished particles quantified by the sp. surface area. Differences on surface properties modulate particle interactions, resulting in agglomerates of drug substance and excipient upon actuation with significant different morphologies, observed by microscope, as well as quantified by Marple cascade impactor. These observations allow for a further understanding of the DPI aerosolization and deposition mechanisms. The dissolution and absorption assessment indicates that the presence of lactose may accelerate the drug substance dissolution kinetics, and the FP dissolution can be significantly enhanced when formulated as a spray-dried dispersion particle. Ultimately, the results suggest dissolution testing can be an essential tool to both optimize an innovator DPI and de-risk generics development.