Press Room

East Windsor Township - Princeton, 2nd March, 2001 – Mayor Janice S. Mironov, East Windsor Township, East Windsor, New Jersey and David Hoffman, President, US Operations, Hovione LLC, Princeton, New Jersey, a wholly owned subsidiary of Hovione SA, are pleased to announce East Windsor Township will be the site of Hovione’s Technology Transfer Center (TTC). The TTC will be located on an 8 acre parcel of land just off exit 8 of the New Jersey Turnpike. The site will consist of commercial offices as well as scale-up and development laboratories. Initial occupancy is scheduled for the 1st Quarter 2001 and will provide employment for 26 people with an expansion capability up to 45. According to Mr. Hoffman, East Windsor Township is an ideal location for technology companies servicing the Pharmaceutical Industry due to the township’s proximity to 9 of the world´s major pharmaceutical companies. The township also has an excellent professional community owing to its centralized location between New York and Philadelphia. According to Mayor Janice S. Mironov, “We are pleased to welcome the US corporate  of an international pharmaceutical active ingredients company such as Hovione to our community. Hovione is an exciting addition to the many firms which have recently located corporate offices and facilities in East Windsor Township, whose superior location and great accessibility were important considerations for these firms”. Hovione will offer process development and scale up services, along with quality control/assurance and regulatory support to the pharmaceutical industry. The technical capability of the TTC will mimic that of Hovione’s fully commercial facilities located in Europe and South China for seamless transition to commercial scale production. The TTC will be fully integrated into Hovione’s global quality network offering US customers real-time data and regulatory support for on-going production in Europe and China. CUH2A, Inc. (Princeton, NJ) has been appointed as the architectural engineering firm and Engineered Technologies Corporation, (Providence, RI) the equipment manufacturer for the TTC. Bids are currently under consideration for the construction and build-out of the facility. Hovione is a global manufacturing company committed to the Pharmaceutical Industry. The principle area of focus is providing specialized technical skills to solve complex problems associated with the development and manufacture of the key active ingredients used in medicines.

Press Release

Hovione locates US Operations in East Windsor Township

Mar 03, 2001

(transcribed and translated at Hovione) The reason for this visit is very simple: It was recently decided by both the Government and all social partners, that we would get together to work with well defined objectives, with a view to significatively improving, here in Portugal, both hygiene, safety at work and our fight against accidents, as well as increasing training and qualification of people at work who create prosperity. It is important to say that on signing the agreement relating to hygiene and safety at work, we assumed that, unfortunately, our Country, is lacking in these fields and, in certain sectors, has an accident rate which is intolerable both from a political and moral point of view relative to the people who work and live in Portugal. It could be thought that these objectives are utopic, but the best way to show that this is not so, is to visit a company that for a long time, and at its own initiative and according to its own strategy, is a centre of excellence. This I take as an example that the Country should know about, not only, but also, in relation to the question of safety. This is the best way to prove to those who do not have this preoccupation sufficiently in mind, what they can and should do and by doing so would not necessarily increase their costs, on the contrary, as has just been mentioned, they could even lower their production costs. Obviously, safety is not exclusively a worry for firms. The State, as regulator and inspector - must recognize that not having done enough in this field is a worry for the firms – but it is also the responsibility of those who work to behave in a matter that safeguards themselves and others. We felt that it was very important that the Country should know Hovione because what is done here in this field is absolutely exemplary and can and should, bearing in mind that natural adaptations required according to the different forms of the country’s economic activity, be copied across the Country, showing that the objectives we have set ourselves, on a country wide scale, are perfectly attainable. Actually, I must refer to another aspect that mentioned here. We have established in our social agreements the right to training. This right, independently from other aspects, assures that all Portuguese workers by 2005 will enjoy 35 hours/year of training. Hovione already offers 70 hours/year training. It is also interesting that training is not something that has been imposed, as a luxury or a political option. In a firm of excellence that assures high standards of technology and is a name in the marketplace, training is an essential component for its own success. At the same time, in this world of constant mutation, it is fundamental to give people the capacity to reply to challenges that are renewed daily as a result of the rapid technological evolution that we live with. But it would be unjust if I did not take advantage of this occasion to state, in the name of the Government, our great appreciation of what Hovione means to Portugal, and not only in what refers to the questions of safety and training. It is a case of quite exemplary capacity for technological innovation and the proof that when we want to, when we really do everything we can and with enormous determination, the conditions exist in Portugal to do as well as anywhere in the world. However, this is not viable without enormous investment, tremendous dedication, effort and competence. I know that several decades ago, Eng. Ivan Villax started in a small laboratory in a cellar. From that small laboratory to what we see here today, there are decades of hard work, of competence, of intelligence which, put to work towards an ideal, assured the building of this enterprise. I feel this is an example to be followed as it demonstrates that it is possible, in Portugal, to achieve the best there is in the World and to have things for which we can be proud from every angle. Such as the matters related to technological capacity, innovation, optimization of management, to all those equally important matters of safety and training in social conscience and of belonging to a community. Many firms tend to function isolated from the community without realizing the importance of being part of it. It is also exemplary that this firm has understood that they can only win by maintaining a constant dialogue with the local community enrichening it at the same time. For all of this, many thanks for this opportunity for the country, more than for myself as I have known of the tradition of excellence that you represent, to grow in self esteem and understand that they too can achieve their own objectives if there is the will and the capacity to do so. Many thanks.

Press Release

Speech delivered by Mr. António Guterres, Prime Minister

Feb 21, 2001

This year Hovione celebrates its 40th anniversary in the field of Active Pharmaceutical Ingredient (API) chemistry and, simultaneously, establishes the basis of its strategy for the next millenium. We have chosen this date to mark a milestone in the evolution of the Company, so as to represent the maturity we have attained as we look back over two generations of progressive growth. Celebrating the past and the future, Hovione assesses it’s management system, strategy and image to reflect our experience as well as our technical and scientific competence. Our future success, like our past, will be based on enhancing our API expertise and on meeting the continuous challenges of the Pharmaceutical Industry. Hovione was founded in Portugal in 1959 by a Hungarian chemist, Ivan Villax, who carried out investigation in the field of semi-synthetic tetracyclines and anti-inflammatory corticosteroids. Behind us are 40 years of accumulated API knowledge described in over 100 innovative process chemistry patents. As we continue to focus on the development and production of active pharmaceutical ingredients, the Company feels well positioned to meet the outsourcing needs of the Pharmaceutical Industry. Hovione has carved a niche for itself synthesizing complex APIs which are highly regulated. Our objectives demand the highest standards of professional competency. Combining focused expertise with quality and state-of-the-art technology, Hovione has become an essential provider to Pharmaceutical Companies worldwide. Hovione not only garantees the development of chemical processes and industrial synthesis of APIs, but offers its customers the technical services that include: Lab scale development Optimization and validation of chemical processes at pilot and industrial scale Kilo-lab and pilot-scale regulated production, including clinical supplies Analytical method development and validation Regulatory filings for IND, NDA (DMF or CMC sections) world-wide Manufacturing contracts for tens of kilos to tens of tons Over the past 10 years Hovione’s evolution entered a new phase as a result of our medium term project, I&DEIA XXI, made possible by the availability of European Community funds destined towards the innovation of Portuguese Industry. In 1987 Hovione had worldwide sales of US$14m and employed a staff of 280. Today, after an investment of over US$45m, the Company invoices about US$50m and employs 500 people. During the last decade, Hovione achieved an increased professionalism in market analysis and product development strategy, and evolved from a family orientated concern to a model of professional and global management. Hovione’s business strategy is based on a deeply rooted knowledge of our target markets: the U.S.A., Japan and the EU. Our factory in Macau, established 15 years ago, benefits from its proximity to the People’s Republic of China for the supply of raw materials. Hovione exports 100% of its production to the most demanding markets in the world, half of which are of products launched less than 5 years’ ago. We invest 8% of sales in R&D, 6% in environmental protection and 5% in quality. Our plants are ISO9000 certified and regularly inspected by the US Food and Drug Administration. With 500 staff worldwide, of which a 100 are at the plant in Macau, Hovione is happy and proud to celebrate 40 years of expertise in API chemistry.

Press Release

40 Years of Expertise in API Chemistry

Jun 01, 1999

Contrast Media is one of two important areas that Hovione defined as key in its 1994 I&DEIA XXI strategic analysis document, the other being offering custom services to the US majors. Hovione is a technology rich company excelling in both difficult chemistry as well as GMP and regulatory affairs. By always tackling the products that others were not interested in because of their difficulty and always taking a pro-active attitude to meeting (instead of avoiding) FDA's increasing severity and tough standards, Hovione is now well equipped to serve the outsourcing needs of the largest US pharmaceuticals companies. Contrast media is an area where no independent manufacturer of bulk existed, the first products to come off patent did so less than 12 months ago, so it was an obvious area where Hovione's skills could be turned into dollars. The surprise was how technically difficult this really was. A team of 60 researchers at Hovione worked non-stop for three years. Contrast media is an area of very high barriers to entry: one needs large capacity (to be a player you need a capacity well in excess of 50 tonnes/year), great technical competence (to meet purity levels of 99.8% and near sterile quality of tonne size batches), know-how and the industrial scale technology to recycle tens of thousands of tonnes of solvents, and last but certainly not least you need to have the ability to prepare tens of kilos of paper meeting every one of FDA's requirements. These products are in many occasions injected, in a single dose, in quantities of 150g. This is the largest parenteral administration of a chemical to a human. Clearly an area only for the most competent and quality generic firms, the market perceives Hovione as such a company.

Press Release

Contrast Media and Custom Services are two key areas in Hovione's strategic analysis document

May 20, 1996

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