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Press Clipping / Nov 12, 2018

Hovione expands production capacity of oral dosage forms

in-PharmaTechnologist, November 12, 2018

The Portuguese CDMO has announced plans to improve production capacity by bringing in commercial scale equipment for blending, tabletting and coating.

The new equipment will work alongside existing smaller scale equipment to offer customers a "one site shop" to take products through the development process to market.

The contract development and manufacturing organisation (CDMO), headquartered in Loures, Portugal, began its expansion project in 2016 and stated that this will continue for the next five years.

The first step of this process began with moving its development services to a 7,000 m2 facility in Lisbon, where the company handles potent and highly potent compounds.

Frédéric Kahn, VP of marketing and sales at Hovione, explained, "Our customers now see drug product manufacturing at the site where they produce their drug product intermediate as a natural extension of the range of value-added services they expect from us. They want to keep their product in the same capable hands."

The CDMO announced that the capacity expansion would be completed alongside the qualification of its continuous tabletting line, which it expects to be completed by the end of 2018.

Hovione completed its continuous manufacturing installation at its New Jersey, US, site at the end of last year - after doubling the size of the development and manufacturing operations.

 

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Integrated approach simplifies development, reduces risk, and supports scalable manufacturing. Hovione and Industrial Design Consultancy Ltd.’s (IDC) lead single-use nasal dry powder device is now available for commercial partnerships. Hovione and IDC have completed the device design and established initial device manufacturing and supply capability, enabling pharmaceutical partners to leverage existing capsule filling infrastructure. This approach simplifies development, reduces cost and risk, and helps shorten timelines to the clinic and commercialization. “This milestone marks an important step in the evolution of our collaboration with IDC — from device innovation to a fully integrated intranasal drug delivery platform,” said Márcio Temtem, Ph.D., Vice President, Strategic Business Management, Hovione. “As the industry looks for faster, more reliable ways to bring complex therapies to patients, integration becomes critical. By bringing together nasal particle engineering science, formulation manufacturing and filling, and device technologies into a single offering, we enable a more seamless and predictable development journey, accelerating the path to market for intranasal therapies.” The nasal delivery device enables broad and targeted nasal deposition flexibility while delivering maximum usability and reliability. With a patented design and manufacturing process established, the platform is available for partnering with pharmaceutical companies on an exclusive basis as part of Hovione’s integrated offering for inhalation and nasal drug development and manufacturing. Additionally, IDC’s Managing Director, Stephen Knowles Ph.D., said the companies are now “well-advanced” with the development of a multi-use device to support an even wider range of therapies and patient needs. Read the full article at ContractPharma.com    

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