Press Room

Webinar - Analytical Sciences of Amorphous Solid Dispersions

Start
Thursday, October 01, 2020 - 16:00
End
Thursday, October 01, 2020 - 16:00
Location: online

Thursday, October 1st, 2020  |  8 AM (PDT), 11 AM (EDT), 4 PM (GMT)

 

Watch On-Demand Webinar

 

 

Speakers

João Pereira - Team Leader, R&D Analytical Development
Susana Campos - Group Leader, R&D Analytical Development

 

Amorphous solid dispersions (ASDs) are a promising formulation approach to overcome solubility challenges of poorly water-soluble drugs. However, close monitoring of physical transformations is required to ensure both product’s processability and shelf-life. Detection of low-level physical transformations is important not only to evaluate and forecast product’s stability but also to correlate with product performance.

This webinar will present Hovione’s approach for the characterization of amorphous solid dispersions (ASD) throughout manufacturing process and product shelf-life. In detail, the use of orthogonal solid state and particle characterization techniques, such as XRD, DSC, IR, Raman and SEM, will be presented in a few case studies.

In this webinar you’ll learn:

  • How to understand and characterize ASD physical stability

  • What are the most suitable techniques for ASD characterization

  • Linking processability and physical transformations of ASD

Watch On-Demand Webinar

 

 

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Hovione is bringing momentum to the intranasal field after announcing that its lead single-use nasal dry powder device, developed in collaboration with Industrial Design Consultancy Ltd (IDC), is now available for commercial partnerships. The milestone marks the transition from prototype to a fully integrated intranasal drug delivery platform that spans Hovione’s end-to-end partnership capabilities–from API synthesis through advanced formulation and particle engineering to drug product manufacturing, including device supply and advanced analytical tools for nasal performance characterization. The platform’s single-use device is designed to be manufacturable at scale and to leverage existing advanced particle engineering and drug product manufacturing capabilities, a practical advantage that can shorten timelines to clinic and commercialization while reducing development risk and cost. The device’s patented mechanism supports targeted nasal deposition, including access to the upper olfactory region. This enables rapid systemic absorption and potential nose-to-brain delivery pathways that are increasingly important for CNS and emergency-use indications. Beyond the single-use format, Hovione and IDC are advancing a multi-dose variant to broaden applicability across dosing regimens and therapeutic areas. The collaboration is backed by an intellectual property portfolio and initial patent grants, positioning the platform as a turnkey option for pharma partners seeking a single integrated supplier for both drug substance and device. This development arrives as intranasal delivery gains traction for systemic, CNS and rapid-onset therapies. This is precisely the focus of the upcoming 4th Nasal Formulation & Delivery Summit, for which Hovione is a key sponsor. The annual summit unites formulation, delivery and product development leaders to tackle drug-device compatibility, translational preclinical models, and strategies for scalable, regulatory-ready intranasal programs. Hovione’s recent progress will be highly relevant to attendees looking to de-risk nose-to-brain and systemic intranasal programs. Read the full article at News-Medical.net    

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