Knowledge Center

Poster / Dec 06, 2017

Spray Dried Composite Particles: Formulation and Process Parameters, Effect of two API Concentrations and Stability Assessment

  • Maria Palha
  • Raquel Barros
  • Claudia Moura
  • Sara Cardoso
  • Eunice Costa
  • Marcio Temtem
DDL 2017

In dry powders for inhalation the active pharmaceutical ingredient (API) is typically blended with excipients. However, poor drug delivery uniformity is frequently observed and the addition of a second API further increase the complexity of the formulation. In order to overcome these challenges, the engineering of carrier-free composite particles by spray drying (SD) is a suitable alternative.