Knowledge Center

Poster / Dec 07, 2016

Impact of Spray Drying on Superoxide Dismutase Activity in Composite Systems with Optimal Aerodynamic Performance for Dry Powder Inhalers

  • Diana A. Fernandes
  • Raquel Barros
  • Claudia Moura
  • Eunice Costa
  • Maria Corvo
DDL 2016

Inhaled biopharmaceutical formulations are increasingly attractive to treat not only a wide range of respiratory but also systemic diseases given:

  • The lungs large surface area available for drug absorption and the avoidance of first-pass metabolism;
  • Biopharmaceuticals (BP) higher specificity, lower toxicity and more predictable in vivo action over small molecules


Efficient delivery of biopharmaceuticals to the lungs still presents a challenge:

  • The generation of a stable aerosol with adequate aerodynamic properties while preserving the biopharmaceutical (BP) integrity.


Particle engineering technology employed to meet this balance plays a pivotal role – Spray Drying (SD) emerges as a viable candidate:

  • From an inhalation standpoint: Relative simplicity, cost effectiveness and scalability with increased control over key aerosol features;
  • From a biopharmaceutical standpoint: Mild temperature exposure, commercial availability of miniaturized SD set-ups

Goal: Spray Drying assessment as a suitable particle engineering technology for the production of composite inhalable powders featuring a model biopharmaceutical