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Patent / Jan 01, 1972

Polymetaphosphate complexes of .alpha.-6-deoxy-5-hydroxy tetracyclines

  • Ivan Villax
DE 2152476

The title Na phosphate complexes, useful as antibiotics and more sol. in water than the corresponding acid complexes, were prepd. by reaction of the tetracycline with Na hexametaphosphate or HPO3 then NaOH in an inert org. solvent, e.g., DMF, EtOH, MeOH, or CHCl3.