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Patent / Jan 01, 2011

Methods and compounds for the preparation of monofluoromethylated biologically active organic compounds

Authors:

Emilia Leitao

Source:

WO 2011151625

Processes were disclosed for the prepn. of monofluoromethylated org. biol. active compds., such as fluticasone propionate and fluticasone furoate I [R = CH2Me, 2-furanyl, resp.], in the presence of fluorodecarboxylating reagents such as XeF2 and BrF3

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Knowledge Center

Methods and compounds for the preparation of monofluoromethylated biologically active organic compounds

Also in the Knowledge Center

Process for the preparation of tamsulosin and intermediates thereof starting from chiral phenylethylamine and using catalytic hydrogenation as the key step

Process for preparation of fluticasone analogs via esterification of a carbothioic acid

Process for the preparation of flumethasone and its 17-carboxyl-androstene analog

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