Industrial process for the purifn. and removal of residual solvents from iohexol, is presented which is based on the suspension of cryst. iohexol, eventually contg. residual solvents above 100 ppm, a fluid whereit has a low soly., followed by heating, filtration, and drying. This process enables the formation of cryst. iohexol with no residual org. residual solvent above 100 ppm and with increased purity level.