Application of high dose compounds via inhalation for treatment of pulmonary diseases

The invention relates to the delivery of high doses of active pharmaceutical compds. via inhalation for the treatment of pulmonary diseases. A pharmaceutical formulation in the form of a powder suitable for inhalation comprises one or more active pharmaceutical ingredients, such as an antibiotic, a mucolytic agent and/or a buffer, wherein the formulation is free of carrier. A powder formulation comprising doxycycline monohydrate combined with sodium citrate filled into TwinCap devices was exemplified.