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Patent / Jan 01, 2013

Application of high dose compounds via inhalation for treatment of pulmonary diseases

  • Pedro Mendes
  • Isabel Lopes
  • Jason Suggett
  • Phillip Nelson
WO 2013104892

The invention relates to the delivery of high doses of active pharmaceutical compds. via inhalation for the treatment of pulmonary diseases. A pharmaceutical formulation in the form of a powder suitable for inhalation comprises one or more active pharmaceutical ingredients, such as an antibiotic, a mucolytic agent and/or a buffer, wherein the formulation is free of carrier. A powder formulation comprising doxycycline monohydrate combined with sodium citrate filled into TwinCap devices was exemplified.