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Patent / Jan 01, 1973

Antibiotic tetracycline complexes

  • Ivan Villax
FR 2111952

Complexes of doxycycline and its salts with metaphosphoric acid were prepd. that gave higher blood antibiotic levels faster than doxycycline hydrochloride hemiethanolate hemihydrate. Thus 23.1 g doxycycline was treated with 4 g metaphosphoric acid to give 24.9 g of a 1:1-complex.