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Patent / Jan 01, 1973

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione

Authors:
Source:
GB 1397267

16.alpha.,-17-Epoxypregnane-3,11,20-trione was ketalized with HOCH2CH2- OH and then reduced by KBH4 to give the bis(ethylenedioxy) pregnanediol I, which reacted with MeMgBr to give pregnenedione II, after hydrolysis. The 2,4-dibromo deriv. of II was debrominated in DMF contg. Li2- CO3 and LiBr to give the title compd. III.

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