In this work we present a synthetic protocol that enabled the gram-scale preparation of key steroids intermediates designed to undergo a green fluorodecarboxylation. The produced intermediates can be used in the synthesis of important active pharmaceutical ingredients. This methodology was applied to a model drug, fluticasone propionate, a potent corticosteroid used in asthma treatment.

Keywords: Asthma, Fluticasone propionate, Fluorodecarboxylation, Bromofluoromethane