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Article / Feb 13, 2006

Custom Chemicals

C&EN, 13 February 2006

Custom Chemicals: As the global paradigm for the custom manufacturing business continues to shift, providers struggle to differentiate themselves from the competition.

EAST HAS MET WEST. THE DESTINY OF THE CUSTOM chemical business is being shaped not only by the traditional powers in the West but also by emerging companies in the East. European and U.S. fine chemicals producers are fighting to get a foothold in Asia by putting assets there or tapping into low-cost supplies. In the meantime, Indian producers of advanced intermediates and active pharmaceutical ingredients (APIs) have created global stances by acquiring foreign operations.

The evidence is undeniable given the number of high-profile deals in just the past year. Among the larger ones is Indiabased Shasun Chemicals & Drugs' planned purchase of Rhodia Pharma Solutions' custom synthesis operations. Shasun will get two U.K. plants and hydrolytic kinetic resolution, aromatic-bond formation, and radical trifluoromethylation technologies. Rhodia will close operations at the Chambers Works site in New Jersey.

Two months earlier, Nicholas Piramal India Ltd. (NPIL) acquired Avecia's pharmaceutical custom synthesis business, which includes operations in...

 

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The global inhalation contract development and manufacturing organization (CDMO) market is projected to grow from USD 9.13 billion in 2025 to USD 16.68 billion by 2035, reflecting a compound annual growth rate (CAGR) of 5.7% during the forecast period. This growth is driven by the increasing prevalence of respiratory diseases, advancements in inhalation drug delivery technologies, and the rising demand for outsourced manufacturing services in the pharmaceutical industry. The inhalation CDMO market has emerged as a pivotal segment in the pharmaceutical contract development and manufacturing industry. With a rising demand for inhaled therapies for conditions like asthma, COPD, and cystic fibrosis, companies are increasingly outsourcing drug development and production to specialized partners. Inhalation CDMO services cater to both large pharmaceutical corporations and small biotech firms, offering expertise in formulation, device compatibility, regulatory support, and scale-up manufacturing. This market is gaining traction due to the complexity of inhalation drug delivery, which often requires niche technical capabilities and specialized equipment. Outsourcing to an inhalation CDMO allows drug developers to reduce time-to-market while ensuring quality and compliance with global standards. (...) Top Companies Several players dominate the inhalation CDMO market through technological expertise, global reach, and service portfolio diversity: (...) Hovione – Offers particle engineering and inhalation development, with a focus on dry powder inhalers. (...) These companies are continually investing in facilities, talent, and technology to meet evolving customer needs in the inhalation CDMO market.   Read the full article on Pharmiweb.com        

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CDMO Hovione and biotechnology company Firstgene Life Sciences (of Xlife Sciences) have collaborated to advance Hovione’s drug delivery platform for the targeted treatment of Hepatocellular Carcinoma (HCC). “We are proud to advance the development of innovative oncology treatments that address a critical unmet need for precision gene expression at the tissue level,” said Hovione CEO Dr Jean-Luc Herbeaux. The virus-like particle technology will be engineered and functionalised for the specific carcinoma cell type using therapeutically validated AAVs, including a novel primer compound. Hovione will be responsible for molecular engineering, the supply of tailor-made virus-like particles and the execution of proof-of-concept studies. “HCC, the most common liver cancer and a leading cause of cancer-related death, continues to represent a major unmet medical need,” said Firstgene managing director Dr Alexander Zink. “The combination of Hovione’s expertise in complex chemistry and particle engineering and the commercialisation expertise of Xlife Sciences positions Firstgene well to offer patients potential new safe and effective therapy options.”   Read the full article at scientistlive.com    

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