Knowledge Center
Poster / Jan 15, 2020
A fundamental study on strain rate sensitivity of spray dried solid dispersions
Source:
AAPS 2019
PURPOSE
Amorphous solid dispersions (ASD) are a proven method of improving the solubility and bioavailability of poorly soluble compounds. It is important that the resulting ASD has suitable properties for tableting, especially if high doses are required. Amorphous solid dispersions consist of API and a stabilizing polymer. Polymers tend to show plastic deformation behavior, typically prone to yield pressure sensitivity to compression speed. The purpose of this study was to examine spray dried ASD sensitivity to strain rate under compression.
Also in the Knowledge Center
/ May 29, 2025
Mitigating Shear Stress in Spray Drying for RNA‑Loaded Lipid Nanoparticles through Process and Formulation Optimization
Read more
Scientific Article
/ Jun 01, 2025
Improving inhalation delivery of biologics with extra-large particles produced by spray freeze drying
Read more
Scientific Article
/ Jun 20, 2025
Material-sparing method development for liquid-to-solid ratio determination for wet granulation process development
Read more
Scientific Article