Knowledge Center
Patent / Jan 01, 2011
Method for monofluoromethylation of organic substrates to prepare biologically active organic compounds
Source:
WO 2011151624
A process for the prepn. of monofluoromethylated org. biol. active compds. using monofluoromethylated reagents was disclosed. Thus, fluticasone propionate and fluticasone furoate I [R = CH2Me, 2-furanyl, resp.] were prepd. using S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium tetrafluoroborate as monofluoromethylating reagent instead of bromofluoromethane.
Also in the Knowledge Center
/ May 29, 2025
Mitigating Shear Stress in Spray Drying for RNA‑Loaded Lipid Nanoparticles through Process and Formulation Optimization
Read more
Scientific Article
/ Jun 01, 2025
Improving inhalation delivery of biologics with extra-large particles produced by spray freeze drying
Read more
Scientific Article
/ Jun 20, 2025
Material-sparing method development for liquid-to-solid ratio determination for wet granulation process development
Read more
Scientific Article