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Article / 2020

Chalcones: Retrospective synthetic approaches and mechanistic aspects of a privileged scaffold

Keywords: Chalcones, Scaffold, Medicinal Chemistry, Pharmacological activity, Flavones, Flavanones, Isoxazolines, benzothiazepines, Pyrimidines and pyrazolines derivatives

Authors:
  • Emilia Leitao
Source:
Current Pharmaceutical Design, April 3, 2020

This review summarizes the synthetic methodologies used in the last 25 years in the synthesis of chalcones, which are a class of flavonoids having a 1,​3-​diphenyl-​2-​propene-​1-​one backbone. These compounds are considered a hot topic in the field of medicinal chemistry, due to their pharmacological activity and because they are important precursors in the synthesis of heterocyclic compounds with therapeutic applications such as: flavones, flavanones, isoxazolines, benzothiazepines, pyrimidines and pyrazolines derivatives.