REGENERAR is a Horizon Europe-funded project that brings together six partners from three European countries who will work together to revolutionize the treatment of neurological disorders and promote brain repair. 

Facts about the project 

• 3 countries 
• 6 partners  
• € 2,943,233.00 - Total Budget 
• 48 months - Project Duration 
• March 1, 2024 - Start Date 

The challenge 

Stroke and neurodegenerative diseases leave millions of people worldwide with significant limitations in their daily lives. These outcomes result from the limited capacity of the central nervous system to repair itself and replace lost neurons. 

The ambition

REGENERAR aims to revolutionize the treatment of neurological disorders and promote brain repair by reprogramming glial cells into neurons. This will be achieved by developing a non-viral formulation to reprogram glial cells into neurons with an unprecedented level of efficiency and safety. 

The approach 

The REGENERAR consortium will evaluate the viability of brain cell reprogramming for clinical use by integrating: 

• Advanced formulations for the treatment of brain diseases 

• Rigorous safety testing using advanced in vitro cellular models and in vivo animal models 

• Preclinical development in compliance with good laboratory practices (GLP) 

Project outcomes 

• Development of a non-viral formulation for brain cell reprogramming 

• Proof-of-concept demonstration of brain cell reprogramming both in vitro and in vivo 

• Advancement of knowledge and education in cellular reprogramming 

Project coordination 

Universidade de Coimbra (UC) 

Center for Neuroscience and Cell Biology 

Hovione Work Package Leaders

	Eunice Costa  R&D Program Director
	Patrícia Henriques R&D Inhalation and Advanced Drug Delivery, Scientist
	Susana Ramos R&D Analytical Development, Senior Analytical Scientist
	Andreia Sofia Pereira R&D Inhalation and Advanced Drug Delivery, Scientist
	Beatriz Jesus MSc Student