Knowledge Center

Patent / Jan 01, 1978

Recovery of doxycycline and products

Authors:
  • Ivan Villax
Source:
US 4061676

Doxycyline, prepd., e.g., by hydrogenation of 11a-chloro-6-deoxy-6-demethyl-6-methylene-5-hydroxytetracycline, was purified by heating the reaction mixt. with concd. HCl, pptn. with 5-sulfosalicylic acid, neutralization, salt formation with HCl, then pptn. as the complex with PhCH2NHCH2CH2NHCH2Ph and Ca ion.

Also in the Knowledge Center

Related Content

Process Safety

Process safety is a blend of engineering and management skills that focuses on the prevention of events impacting safety, environmental damage and business losses.

Page
Read more

Manufacturing

Hovione has extensive manufacturing capacity in Particle Engineering providing the right scale and flexibility for all our customers.

Page
Read more

Drug delivery platforms

Hovione has unique capabilities and expertise in solubility enhancement, lung delivery, modified release and taste-masking applications.

Page
Read more