Knowledge Center

Patent / Jan 01, 1976

Preparation of steroids

Authors:
  • Ivan Villax
Source:
GB 1397267

17-Hydroxy-16.beta.-methylpregna-1,4,9(11)-triene-3,20-dione (I) was prepd. from epoxypregnanetrione II. Thus, II was ketalized using HOCH2CH2OH followed by KBH4 redn., the 11.beta.-hydroxy deriv. was mesylated-demesyloxylated, the 9(11)-unsatd. deriv. was condensed with MeMgBr and then hydrolyzed to give 17-hydroxy-16.beta.-methyl-5.beta.-pregn-9(11)-ene-3,20-dione (III). Bromination-dehydrobromination of III with subsequent dehydrogenation gave I.

Also in the Knowledge Center

Related Content

Hovione and Zerion Pharma create joint venture to further expand use of Dispersome® technology

Press Release / Oct 03, 2024
Article
View

Wet Polishing

This is a proprietary Hovione technology for addressing complex particle reduction challenges.

Page
Read more

Dispersome®

Make your drug soluble with Dispersome® technology. Dispersome® is a solubility enhancement technology that relies on an innovative and naturally occurring excipient to develop amorphous solid dispersions with high drug loading and high bioavailability.

Page
Read more