A method of preparing amorphous solid dispersion in submicron range by co-precipitation
The present invention discloses a method for producing amorphous solid dispersions in a nanoparticulate form, through solvent controlled co-pptn., using microfluidization/microreaction technol. to promote high energy mixing/interaction at a micro and/or mol. level between the streams involved in the process. Feed streams, solvent and anti-solvent, are fed to an intensifier pump at individually controlled rates and forced to interact to micro-and/or nano-scale within a microreactor. The present invention also discloses amorphous solid dispersions obtained by the method of the invention as well as pharmaceutical compns. contg. the same.