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Poster / Oct 18, 2021

Ring Shear Tester: The importance of Shear and Wall Friction Methodology for Arching Tendency Predictions

Hovione poster at AAPS 2021 PharmSci 360

Authors:
  • Maria Paisana
Source:
AAPS 2021

Track: Manufacturing and Analytical Characterization – Chemical
Monday, October 18, 2021 | 10:30 AM – 11:30 AM ET

Presenting Author: Maria Paisana - Senior Analytical Scientist, Analytical Development Group

This work was focused on the analyses of pharmaceutical excipients and active pharmaceutical ingredients by a ring shear tester (RST-XS.s) using different shear and wall friction cells at different stresses. The work aimed at developing a methodology to obtain accurate predictions of powder flow through hoppers with different dimensions. In detail, the yield locus and the wall yield locus data obtained for different materials were treated mathematically and data was validated by discharging the powders through hoppers with different wall angles.

More details on PharmSci360