Biorelevant Dissolution Testing of Orally Inhaled Drugs
Adding a Newly Designed Pre-separator to PreciseInhale®
Dissolution testing can be a way of discriminating between different formulations; still, currently there are no standard apparatus or procedures available for inhaled products.
... developed an in vitro model that simulates the dissolution and absorption of drugs from inhaled aerosols - Dissolvlt®. Prior to dissolution testing, products are aerosolized and collected on coverslips using the PreciseInhale® aerosol generator. However this collecting equipment lacks an impaction stage for coarse particle and agglomerates - a pre-separator - , thereby decreasing the biorelevance of succeeding dissolution test.