Press Room

News / May 13, 2021

Hovione Virtual Run

The biggest race in Loures - Portugal is back and it's virtual!

The Hovione Run is back, in virtual format! The biggest race in Loures/ Portugal, this year goes global and will have national and international participants.

Between the 4th, 5th and 6th of June, athletes will be able to travel one of the three distances available:

Virtual Run | Hovione

Registration is completely free.

REGISTER HERE

 

AWARDS

  • Virtual finisher medal
  • Diploma to be consulted in the results menu of the website www.xistarca.pt *
  • Virtual cup for the top 3 male and female runners from each distance

* At the end of the race, you must answer a questionnaire, which will be sent to all registered participants and which will also be available on this page, indicating the race time and a photo that proves the same.

 

CLASSIFICATIONS

The general classification will be published on the event’s website, taking as correct the information that will be sent to the organization, not being approved for competitive purposes.

 

Learn more at www.xistarca.pt

 

 

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Continuous Tableting (CT) is defined as continuous manufacturing of oral dose drugs, specifically tablets. As per ICH's Q13 definition1, a continuous manufacturing process in the pharmaceutical industry comprises at least two unit operations integrated from a mechanical and software perspective. There is a wide combination of possible CT process configurations that are dependent on the needs of the intended product formulation and each of the individual unit operations that constitute the process train can be continuous, semi-continuous, or batch processes. The typical manufacturing processes for tablet formulation are direct compression (DC), dry granulation (DG) and wet granulation (WG)2 - details on these manufacturing processes are beyond the scope of this article, so the interested reader is directed to relevant literature. The actual implementation of CT technology in a facility can broadly vary depending on the level of desired integration and automation. Process trains can be designed to be flexible and converted between multiple configurations (e.g. continuous DC, DG and WG), controlled by the end user from one single software and within a single clean room. The other possibility would be for subsections of the CT process to be divided into multiple clean rooms where inprocess materials are transferred between suites via a bin-to-bin approach (e.g. a granulation suite to prepare granules from raw materials followed by continuous DC (CDC) to blend the granules and produce tablets). The level of automation and instrumentation designed into the CT process (typically involving Process Analytical Technologies, PAT) can open the possibility to implement sophisticated control strategies. Key components of a control strategy that need to be considered for CT are material tracking and genealogy, knowledge of the residence time distribution (RTD), and in-process controls (spectroscopic and/or soft sensors based on process parameters). Holistically, these control strategy elements enable the implementation of a material diversion strategy to automatically divert out of specification material from the process. In their most advanced form, control strategies may also enable real time release testing (RTRt) of the final tablet drug product and reduce the off-line analytical burden and the number of operators needed to manage the process.   Read the full article at gmp-journal.com  

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Continuous Tableting and the Road to Global Adoption

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