Press Room

RDD 2021

Start
Tuesday, May 04, 2021 - 00:00
End
Friday, May 07, 2021 - 00:00
Location: online
Continuous Manufacturing Drug Product Commercial Supply | Hovione

If you would like to find more about Hovione's full range of inhalation development servicesparticle engineering and development by design schedule a meeting with us.

 

steve-landelius-photo

Steven Landelius

Business Development Manager

 

 

Schedule a meeting button | Hovione

From May 4-7, do not miss Hovione's Scientists Presentations at RDD 2021 virtual conference.

 

WORKSHOP
PRESENTATION

Fully Integrated DPI Development – From API To Device
João Pereira and Beatriz Noriega Fernandes

 

What will you learn?
  • How to choose a suitable API formulation
  • How to select the right particle engineering technology
  • Novel techniques for inhalation products characterization
  • Advanced solutions for inhalation platforms

POSTERS

Comparison of Two Drug Micronization Methods Using Multiple Physiochemical Characterization Techniques
Sara Perico

 

Understanding Particle Friability Through Solid State Characterization
Ruben Chaves

ABSTRACTS

Amorphous Solid Dispersions for Nasal Delivery: Development, Characterization and Performance Studies
Patricia Henriques

 

Our experts are available to listen and understand your projects. Together we can speed up your Inhalation drug development, with less regulatory hurdles, less time, and less costs.

 

 
Drug Product Facility in Portugal | Hovione

 

 

Hovione Inhalation Development Virtual Tour (click on the image to watch video)

Meet Eunice Costa, Hovione’s group leader for Inhalation Development and visit the site where all the team sits together.

 

 

Also in the Press Room

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Continuous Tableting (CT) is defined as continuous manufacturing of oral dose drugs, specifically tablets. As per ICH's Q13 definition1, a continuous manufacturing process in the pharmaceutical industry comprises at least two unit operations integrated from a mechanical and software perspective. There is a wide combination of possible CT process configurations that are dependent on the needs of the intended product formulation and each of the individual unit operations that constitute the process train can be continuous, semi-continuous, or batch processes. The typical manufacturing processes for tablet formulation are direct compression (DC), dry granulation (DG) and wet granulation (WG)2 - details on these manufacturing processes are beyond the scope of this article, so the interested reader is directed to relevant literature. The actual implementation of CT technology in a facility can broadly vary depending on the level of desired integration and automation. Process trains can be designed to be flexible and converted between multiple configurations (e.g. continuous DC, DG and WG), controlled by the end user from one single software and within a single clean room. The other possibility would be for subsections of the CT process to be divided into multiple clean rooms where inprocess materials are transferred between suites via a bin-to-bin approach (e.g. a granulation suite to prepare granules from raw materials followed by continuous DC (CDC) to blend the granules and produce tablets). The level of automation and instrumentation designed into the CT process (typically involving Process Analytical Technologies, PAT) can open the possibility to implement sophisticated control strategies. Key components of a control strategy that need to be considered for CT are material tracking and genealogy, knowledge of the residence time distribution (RTD), and in-process controls (spectroscopic and/or soft sensors based on process parameters). Holistically, these control strategy elements enable the implementation of a material diversion strategy to automatically divert out of specification material from the process. In their most advanced form, control strategies may also enable real time release testing (RTRt) of the final tablet drug product and reduce the off-line analytical burden and the number of operators needed to manage the process.   Read the full article at gmp-journal.com  

Article

Continuous Tableting and the Road to Global Adoption

Mar 04, 2024