Press Room

RDD 2016

Start
Sunday, April 17, 2016 - 00:00
End
Thursday, April 21, 2016 - 23:45
Location: Arizona, USA
Booth Number: 14

The Respiratory Drug Delivery (RDD®) 2016 will be held at the Westin Kierland Resort, Phoenix, Arizona, April 17-21, 2016.

Hovione will be present with a table and a set of posters.

 

HOVIONE'S POSTERS

Particle Engineered Glycopyrrolate Inhalation Grade: A Comprehensive Solid State Characterization Study
Susana Campos

From TwinCaps® to TwinMax™: Optimizing a Disposable Inhaler for High Dosage Applications Through CFD
João Fernandes

Impact of the API Concentration on the Solid State Properties and Aerodynamic Performance of Composite Particles for DPIs
Diana Fernandes

Strategies to Deliver Doxycycline Monohydrate via Inhalation
Maria Palha

Alternatives to Lactose-only Carrier-based Formulations: The Use of Mannitol and Magnesium Stearate
Bruno Santos

Using Laser Diffraction for the Advanced Characterization of Nebulization Products - Part 1: Discriminative Power via Standard Data Analysis
Isabel Sequeira Lopes

Using Laser Diffraction for the Advanced Characterization of Nebulization Products - Part 2: Extended Data Analysis and Correlation with Cascade Impaction
Isabel Sequeira Lopes

Dry Powder Inhalers Characterization: Comparison Between Full and Abbreviated Impactor Testing
Sofia Silva

 

Details about the event
To find more about the posters, contact us

Also in the Press Room

See All

Continuous Tableting (CT) is defined as continuous manufacturing of oral dose drugs, specifically tablets. As per ICH's Q13 definition1, a continuous manufacturing process in the pharmaceutical industry comprises at least two unit operations integrated from a mechanical and software perspective. There is a wide combination of possible CT process configurations that are dependent on the needs of the intended product formulation and each of the individual unit operations that constitute the process train can be continuous, semi-continuous, or batch processes. The typical manufacturing processes for tablet formulation are direct compression (DC), dry granulation (DG) and wet granulation (WG)2 - details on these manufacturing processes are beyond the scope of this article, so the interested reader is directed to relevant literature. The actual implementation of CT technology in a facility can broadly vary depending on the level of desired integration and automation. Process trains can be designed to be flexible and converted between multiple configurations (e.g. continuous DC, DG and WG), controlled by the end user from one single software and within a single clean room. The other possibility would be for subsections of the CT process to be divided into multiple clean rooms where inprocess materials are transferred between suites via a bin-to-bin approach (e.g. a granulation suite to prepare granules from raw materials followed by continuous DC (CDC) to blend the granules and produce tablets). The level of automation and instrumentation designed into the CT process (typically involving Process Analytical Technologies, PAT) can open the possibility to implement sophisticated control strategies. Key components of a control strategy that need to be considered for CT are material tracking and genealogy, knowledge of the residence time distribution (RTD), and in-process controls (spectroscopic and/or soft sensors based on process parameters). Holistically, these control strategy elements enable the implementation of a material diversion strategy to automatically divert out of specification material from the process. In their most advanced form, control strategies may also enable real time release testing (RTRt) of the final tablet drug product and reduce the off-line analytical burden and the number of operators needed to manage the process.   Read the full article at gmp-journal.com  

Article

Continuous Tableting and the Road to Global Adoption

Mar 04, 2024