Press Room

Digital RDD 2020

Start
Sunday, April 26, 2020 - 00:00
End
Tuesday, June 30, 2020 - 00:00
Location: online

RDD 2020 and IPAC-RS in Desert Springs, California, April 26-May 1, 2020 are canceled. The organization is holding the Digital RDD 2020.

 

Digital RDD 2020 is open 24/7 until June 30

 

HOVIONE DIGITAL PRESENTATION:

  • Title: “Spray Dried Particles for Inhalation: Process Development Following a QbD Approach”
    João Henriques, PhD, Hovione, Lisbon, Portugal

 

HOVIONE DIGITAL POSTER:

  • Title: “Spray-dried Microparticles vs. Chimeral Agglomerates for Nasal Powder Delivery: Characterization and Aerodynamic Performance"
    Patricia Henriques, PhD Student, R&D DPD, Hovione, Lisbon, Portugal

 

 

If you would like to find more about Hovione's full range of inhalation development servicesparticle engineering and development by design schedule a meeting with us.

Schedule a meeting button | Hovione

Our colleague Steve Landelius will be pleased to meet you.

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Steven Landelius

Business Development Manager
 

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Continuous Tableting (CT) is defined as continuous manufacturing of oral dose drugs, specifically tablets. As per ICH's Q13 definition1, a continuous manufacturing process in the pharmaceutical industry comprises at least two unit operations integrated from a mechanical and software perspective. There is a wide combination of possible CT process configurations that are dependent on the needs of the intended product formulation and each of the individual unit operations that constitute the process train can be continuous, semi-continuous, or batch processes. The typical manufacturing processes for tablet formulation are direct compression (DC), dry granulation (DG) and wet granulation (WG)2 - details on these manufacturing processes are beyond the scope of this article, so the interested reader is directed to relevant literature. The actual implementation of CT technology in a facility can broadly vary depending on the level of desired integration and automation. Process trains can be designed to be flexible and converted between multiple configurations (e.g. continuous DC, DG and WG), controlled by the end user from one single software and within a single clean room. The other possibility would be for subsections of the CT process to be divided into multiple clean rooms where inprocess materials are transferred between suites via a bin-to-bin approach (e.g. a granulation suite to prepare granules from raw materials followed by continuous DC (CDC) to blend the granules and produce tablets). The level of automation and instrumentation designed into the CT process (typically involving Process Analytical Technologies, PAT) can open the possibility to implement sophisticated control strategies. Key components of a control strategy that need to be considered for CT are material tracking and genealogy, knowledge of the residence time distribution (RTD), and in-process controls (spectroscopic and/or soft sensors based on process parameters). Holistically, these control strategy elements enable the implementation of a material diversion strategy to automatically divert out of specification material from the process. In their most advanced form, control strategies may also enable real time release testing (RTRt) of the final tablet drug product and reduce the off-line analytical burden and the number of operators needed to manage the process.   Read the full article at gmp-journal.com  

Article

Continuous Tableting and the Road to Global Adoption

Mar 04, 2024