Press Room

2021 CPhI Japan

Start
Wednesday, April 14, 2021 - 00:00
End
Friday, April 30, 2021 - 00:00
Location: Osaka, Japan
Drug Product Dry Granulation | Hovione

If you are attending CPhI Japan and would like to chat with us about your challenges, schedule a meeting with us. Yasushi Usuda will be pleased to meet you.

With more than 25 years’ experience in Inhalation, Hovione is your solution partner from early proof-of-concept to commercial scale manufacture.

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Yasushi Usuda

Director of Japan Office

 

 

CPhI Japanに出展するホビオンをご覧ください。また、今から面談をご予約しませんか。

​​​​​Visit Hovione at CPhI Japan Connect and schedule a meeting.

 

 

Webinar (available in English)

Title: “Leveraging Particle Engineering towards the Delivery of Biopharmaceuticals”

Date/ Time: April 15th, 2:00 pm JST

 

Watch On-Demand Webinar

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Biopharmaceuticals represent the most promising and fastest-growing field in the pharmaceutical area. These therapeutics show very high specificity and potency at relatively low concentrations and enable the treatment of otherwise untreatable diseases.

 

 

What can you learn from this webinar?

  • Formulation screening for biologics
  • Spray drying of monoclonal antibodies
  • Spray freeze drying
  • Pulmonary Delivery of enzymes
  • A series of case-studies will also be shown for each of the relevant technologies.
     

Speakers:

Paulo Lino, PhD - Scientist, R&D Drug Product Development
João Sá, PhD - Scientist, R&D Drug Product Development

 

 

Watch On-Demand Webinar

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Our experts are available to address all challenges, helping your projects to succeed.

 

Schedule a meeting button | Hovione

 

 

 

 

Also in the Press Room

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Continuous Tableting (CT) is defined as continuous manufacturing of oral dose drugs, specifically tablets. As per ICH's Q13 definition1, a continuous manufacturing process in the pharmaceutical industry comprises at least two unit operations integrated from a mechanical and software perspective. There is a wide combination of possible CT process configurations that are dependent on the needs of the intended product formulation and each of the individual unit operations that constitute the process train can be continuous, semi-continuous, or batch processes. The typical manufacturing processes for tablet formulation are direct compression (DC), dry granulation (DG) and wet granulation (WG)2 - details on these manufacturing processes are beyond the scope of this article, so the interested reader is directed to relevant literature. The actual implementation of CT technology in a facility can broadly vary depending on the level of desired integration and automation. Process trains can be designed to be flexible and converted between multiple configurations (e.g. continuous DC, DG and WG), controlled by the end user from one single software and within a single clean room. The other possibility would be for subsections of the CT process to be divided into multiple clean rooms where inprocess materials are transferred between suites via a bin-to-bin approach (e.g. a granulation suite to prepare granules from raw materials followed by continuous DC (CDC) to blend the granules and produce tablets). The level of automation and instrumentation designed into the CT process (typically involving Process Analytical Technologies, PAT) can open the possibility to implement sophisticated control strategies. Key components of a control strategy that need to be considered for CT are material tracking and genealogy, knowledge of the residence time distribution (RTD), and in-process controls (spectroscopic and/or soft sensors based on process parameters). Holistically, these control strategy elements enable the implementation of a material diversion strategy to automatically divert out of specification material from the process. In their most advanced form, control strategies may also enable real time release testing (RTRt) of the final tablet drug product and reduce the off-line analytical burden and the number of operators needed to manage the process.   Read the full article at gmp-journal.com  

Article

Continuous Tableting and the Road to Global Adoption

Mar 04, 2024