Knowledge Center

Poster / Dec 07, 2016

Optimization of Supercritical CO2 Assisted Spray Drying for the Production of Inhalable Composite Particles

  • Claudia Moura
  • Eunice Costa
DDL 2016

New strategies of carrier free inhaled drug delivery are possible due to advances in the particle engineering field, in which Spray-drying (SD) is one of the most well-known. However, due to the environmental deterioration, the exploration and use of alternative greener technologies should be encouraged. For this reason, the production of composite particles using super critical fluids, namely, Supercritical-CO2 Assisted Spray Drying (SASD) was investigated, using supercritical carbon dioxide (scCO2) as a cosolvent to assist the atomization process, minimizing the use of solvents.