Press Room

AAPS 2017

Start
Sunday, November 12, 2017 - 00:00
End
Wednesday, November 15, 2017 - 00:00
Location: San Diego, United States
Booth Number: 2806
Spray Drying Contract Manufacturing large capacity | Hovione

Hovione will be attending AAPS 2017 in San Diego, United States.

Schedule meeting - AAPS 2017| Hovione

HOVIONE POSTERS

Benchmarking melt processing techniques for taste masking applications
Slavomira Doktorovova, Inês Matos, Peter Stayer, Márcio Temtem, João Henriques

Bio-relevant vs traditional dissolution methodologies: a comparison study between USP II and USP IV apparatuses
Mafalda Paiva, Luís Sousa, Pedro Serôdio, Constança Cacela

Optimizing Disintegration in Tablets of Amorphous Solid Dispersions
Nuno Neves, João Henriques, Márcio Temtem

Enhancing Amorphous Solid Dispersion Miscibility and Drug Saturation through Ternary Systems
Traciann Scirbona, Michael Puppolo, Iris Duarte, João Henriques, Rui Ferreira, David Storey, Dirce Macário

Compression mechanism of HPMC-AS based amorphous solid dispersions
Slavomira Doktorovova, Clara Sá Couto, Márcio Temtem, João Henriques, Pedro Valente

Improving Efficiency of Taste Making through Spray Congealing
Inês Matos, Peter Stayer, João Henriques, Márcio Temtem

In vitro - in vivo correlations of carbamazepine nano-dispersions for application in formulation development
Michael Puppolo, Zachary WarnkenIris Duarte, Traciann Dillon, David Storey

Paddle Over Disk as a Dissolution Test for Orally Inhaled Fluticasone Propionate
Beatriz Noriega, Mafalda Paiva, Luisa Corvo, Eunice Costa, Filipa Maia

Spray Dried Composite Particles: Formulation and Process Parameters, Effect of two API Concentrations and Stability Assessment
Maria Palha, Raquel Barros, Cláudia Moura, Sofia Silva, Sara Cardoso, Eunice Costa, Márcio Temtem

Use of Supercritical-CO2 Assisted Spray Drying for the production of Pharmaceutical compounds
Cláudia Moura, Márcio Temtem, Eunice Costa

 

 

If you would like to discuss with us your projects and to find how Hovione can help, schedule a meeting with us. Adam Neunuebel will be pleased to meet you.

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Adam Neunuebel

Head of Business Development

 

 

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Continuous Tableting (CT) is defined as continuous manufacturing of oral dose drugs, specifically tablets. As per ICH's Q13 definition1, a continuous manufacturing process in the pharmaceutical industry comprises at least two unit operations integrated from a mechanical and software perspective. There is a wide combination of possible CT process configurations that are dependent on the needs of the intended product formulation and each of the individual unit operations that constitute the process train can be continuous, semi-continuous, or batch processes. The typical manufacturing processes for tablet formulation are direct compression (DC), dry granulation (DG) and wet granulation (WG)2 - details on these manufacturing processes are beyond the scope of this article, so the interested reader is directed to relevant literature. The actual implementation of CT technology in a facility can broadly vary depending on the level of desired integration and automation. Process trains can be designed to be flexible and converted between multiple configurations (e.g. continuous DC, DG and WG), controlled by the end user from one single software and within a single clean room. The other possibility would be for subsections of the CT process to be divided into multiple clean rooms where inprocess materials are transferred between suites via a bin-to-bin approach (e.g. a granulation suite to prepare granules from raw materials followed by continuous DC (CDC) to blend the granules and produce tablets). The level of automation and instrumentation designed into the CT process (typically involving Process Analytical Technologies, PAT) can open the possibility to implement sophisticated control strategies. Key components of a control strategy that need to be considered for CT are material tracking and genealogy, knowledge of the residence time distribution (RTD), and in-process controls (spectroscopic and/or soft sensors based on process parameters). Holistically, these control strategy elements enable the implementation of a material diversion strategy to automatically divert out of specification material from the process. In their most advanced form, control strategies may also enable real time release testing (RTRt) of the final tablet drug product and reduce the off-line analytical burden and the number of operators needed to manage the process.   Read the full article at gmp-journal.com  

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Continuous Tableting and the Road to Global Adoption

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