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Patent / 2013

Detoxification of Active Pharmaceutical Ingredients For Nano-Filtration

Hovione Farmaciencia, S.A.

Authors:
  • Joao Bandarra
  • Gyorgy Szekely
Source:
PT 105601
The invention describes the use of nanofiltration of org. solvents as a general platform for removing genotoxic impurities, also known as genotoxins, used as a reagent or formed during the synthesis of active pharmaceutical ingredients or their intermediates.  The invention thus focuses, in particular, on the removal of the most common classes of genotoxic impurities using membranes.