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Patent / 1972

Polymetaphosphate complexes of .alpha.-6-deoxy-5-hydroxy tetracyclines

Authors:
  • Ivan Villax
Source:
DE 2152476
The title Na phosphate complexes, useful as antibiotics and more sol. in water than the corresponding acid complexes, were prepd. by reaction of the tetracycline with Na hexametaphosphate or HPO3 then NaOH in an inert org. solvent, e.g., DMF, EtOH, MeOH, or CHCl3.