Knowledge Center
Patent / Jan 01, 1973
16.beta.-Methyl-17-hydroxypregna-1,4,9(11)-triene-3,20-dione
Source:
GB 1397267
The title compd. (I), useful as intermediate for the manuf. of betametasone, was prepd. Partial ketalization of the trioxo compd. (II), KBH4 redn. of the resulting oxo compd. (III), and subsequent dehydration by MeSO2Cl contg. SO3 gave the epoxypregnene (IV). Grignard reaction of IV with MeMgBr gave the methylhydroxy deriv. (V) and subsequent deketalization the dione (VI), which on 2-step bromination-dehydrobromination or 1-step dehydrogenation by dichlorodicyanobenzoquinone led to I.
Also in the Knowledge Center
/ May 29, 2025
Mitigating Shear Stress in Spray Drying for RNA‑Loaded Lipid Nanoparticles through Process and Formulation Optimization
Read more
Scientific Article
/ Jun 01, 2025
Improving inhalation delivery of biologics with extra-large particles produced by spray freeze drying
Read more
Scientific Article
/ Jun 20, 2025
Material-sparing method development for liquid-to-solid ratio determination for wet granulation process development
Read more
Scientific Article