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Patent / 1977

Polyphosphate complexes of 6-demethyl-6-deoxy-6-methylenetetracycline and its 11a-halo derivatives

Authors:
  • Ivan Villax
Source:
ES 420504
5-Hydroxytetracycline 6,12-hemiacetal 12-phosphite was dehydrated by P2O5 to give 6-deoxy-6-demethyl-6-methylene-5-hydroxytetracycline polymetaphosphate. Similarly prepd. was 11a-chloro-6-deoxy-6-demethyl-6-methylene-5-hydroxytetracycline metaphosphate.