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Patent / 1999

A process for the preparation of 4-(des-dimethylamino)-tetracyclines

Hovione Inter Ltd.

Authors:
  • William Heggie
  • Jose Galindro
  • Luis Carvalho
Source:
EP 962552
The present invention refers to a process for the prepn. of 4-(desdimethylamino)tetracyclines, which compds. have a therapeutical application. The starting tetracyclines are treated with a methylating agent and the resulting trimethylammonium salts are reduced by electrolysis aq. soln. at acidic pH, the presence of adequate electrolyte. A direct elec. current with a potential of 0.5-1.5 V is applied between two convenient electrodes until the reaction is complete.