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Patent / 2007

Process for the manufacture of iohexol by the alkylation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide with 1-chloro-2,3-propanediol using 2-(2-methoxyethoxy)ethanol as the reaction solvent

Hovione Inter Ltd.

Authors:
  • Jose Galindro
  • Joao Bandarra
  • William Heggie
Source:
WO 2007060380
A process for the prodn. of iohexol comprises alkylating 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide with 1-chloro-2,3-propanediol using 2-(2-methoxyethoxy)ethanol as the reaction solvent the presence of a base (e.g., sodium hydroxide).