Knowledge Center

Poster / Nov 13, 2016

Aerodynamic Performance of DPIs versus Process Efficiency

A Necessary Compromise

Authors:
  • Filipa Maia
  • Maria Palha
  • Isabel Lopes
  • Filipe Neves
Source:
AAPS 2016
Dry powder inhalers target optimal performance, but should also consider the robustness of the downstream processes. Blend compositions which improve Fine Particle Fraction (FPF5μm/ED) hinder process yield (rejection rate, RR) and device performance (emitted dose, ED). This work establishes relationships between blend rheology, product performance and downstream process efficiency and sets a Design Space which integrates different trade-offs between Product and Process optimization.