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Article / 2016

Dry-Powder Inhalation Formulation: Balancing Performance and Manufacturability

Delivery to the lung is an attractive alternative to parenteral delivery, which is the most common route of administration for biomolecules

Authors:
  • Conrad Winters
  • Eunice Costa
Source:
Pharma's Almanac, Q4 2016, 23 October 2016

There is growing demand for dry-powder inhalation formulations of drugs to treat both respiratory and systemic diseases. Composite particle technology is allowing the development of more efficient formulations, even for challenging molecules. Spray drying is an  enabling technology for composite particle preparation. Formulators must be aware, however, of the tradeoffs between properties that improve aerodynamic performance in the lung but negatively impact  process yields or throughputs.