Hydrogenations

Hovione has vast experience in developing hydrogenation processes using both heterogeneous and homogeneous catalysis.

Hydrogenations

Catalytic hydrogenation is a versatile technology applicable to numerous synthetic transformations. As a consequence, hydrogenation is routinely encountered in drug substance synthesis.

Hovione has vast experience in developing hydrogenation processes using both heterogeneous and homogeneous catalysis and operates this technology up to large commercial scale (100’s MT per annum).  Our development team has a wide range of laboratory scale hydrogenators available (100 mL to 7.5 L) for process development purposes. For subsequent scale up we have extensive pilot and large scale hydrogenation capacity with broad geographic coverage. A summary of the pilot and commercial hydrogenation capabilities is provided below.

Please talk to us if your project would benefit from partnering with an organization with deep expertise in scaling hydrogenations.

Site Reactor capacity Pressure Rating Material of Construction
Loures 100 L 100 bar Hastelloy
  2000 L 25 bar Stainless steel
  3000 L 10 bar Hastelloy
  3000 L 10 bar Stainless stell - 904L
  5000 L 25 bar Hastelloy
Macau 600 L 20 bar Stainless steel
  3000 L 10 bar Stainless steel
Cork 2500 L 6 bar Glass lined
  6000 L 12 bar Stainless steel

 

Also in Drug Substance Capabilities

Chromatography

Hovione has expanded its purification technologies to include chromatography to support development from lab to commercial scale.

Corticosteroids

Corticosteroids are produced in two dedicated buildings on the Loures site, which are equipped with vessels ranging from 50L up to 4000L.

Fluorinations

Hovione has a long history of carrying out reactions using hydrofluoric acid (HF) at commercial scale under a GMP environment.