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Aerodynamic Performance of DPIs versus Process Efficiency
Dry powder inhalers target optimal performance, but should also consider the robustness of the downstream processes. Blend compositions which improve Fine Particle Fraction (FPF5μm/ED) hinder process yield (rejection rate, RR) and device performance (emitted dose, ED). This work establishes relationships between blend rheology, product performance and downstream process efficiency and sets a Design Space which integrates different trade-offs between Product and Process optimization.