Continuous production of particles, micro- and/or nanoparticles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compns.
The present invention discloses a method to continuously manuf. micro- and/or nanoparticles of single component particles or multi-component particles such as particulate amorphous solid dispersions or particulate co-crystals. The continuous method comprises the steps of 1. prepg. a first soln. comprising at least one component and at least one solvent and a second soln. comprising at least one anti-solvent of the at least one component comprised in the first soln., 2. mixing said first soln. and said second soln. by means of microfluidization to produce a suspension by pptn. or co-pptn., 3. feeding said suspension to a filtration system to obtain a conc. stream, 4. feeding said conc. stream to a spray dryer, 5. atomizing said conc. stream using at least one atomization nozzle, 6. drying said atomized conc. stream to obtain particles, and 7. collecting said particles. Single component particles or multi-component particles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compns. are also disclosed. Thus, fluticasone propionate (6 g) was dissolved in acetone (476 g); deionized water was used as the antisolvent; a mass of deionized water corresponding to ten times the mass of the solvent was measured; the pptn. in the form of API particles was performed using a micro-fluidizer reactor comprising a chamber with 75 mm diam. reaction channels followed by an auxiliary processing module with 200 mm diam. reaction channels.